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ARAVA is indicated in adults for that treatment of active rheumatoid arthritis symptoms (RA):


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Take this medicine only as directed by your doctor. Do not take a greater portion of it, don't take it more regularly, and don't take it for a longer time than your physician ordered.

The dose of the medicine will be different for different patients. Follow your medical professional's orders or perhaps the directions on the label. The following information includes just the average doses with this medicine. If your dose is different, tend not to change it out unless your physician informs you to do this.

The quantity of medicine that you simply take depends for the strength in the medicine. Also, the number of doses you adopt daily, enough time allowed between doses, along with the period of time you are taking the medicine depend on the medical problem that you can are employing the medicine.

For oral dosage form (tablets):

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For rheumatism:

If you miss a dose of the medicine, go on it as quickly as possible. However, when it is almost time for your forthcoming dose, skip the missed dose and get back to your regular dosing schedule. Do not double doses.


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Store at 25°C (77°F); excursions allowed to 15-30°C (59-86°F). Protect from light. Keep out with the reach of youngsters. Do not keep outdated medicine or medicine will no longer needed. Store the medicine in a very closed container at room temperature, far from heat, moisture.

 Keep out in the reach of kids. Do not keep outdated medicine or medicine will no longer needed. Store the medicine inside a closed container at room temperature, from heat, moisture.


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Side Effects

Stop by using this medicine and look with a medical expert immediately in case you are having burning, numbness, tingling, or painful sensations within the arms, hands, legs, or feet. These could be the signs of a condition called peripheral neuropathy.

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Adverse reactions for this using leflunomide in RA include diarrhea, elevated liver enzymes (ALT and AST), alopecia and rash.

Along with its needed effects, a medicine could potentially cause some unwanted effects. Although not these unwanted side effects may occur, when they happen they could need medical assistance.

Check with your physician immediately if any with the following side effects occur:
More common
Bloody or cloudy urine
difficult or painful breathing
difficult, burning, or painful urination
frequent urge to urinate
lack of appetite
nausea / vomiting
sore throat
tightness in the chest
yellow eyes or skin
Less common
Burning feeling within the chest or stomach
burning, prickling, or tingling sensation inside the fingers or toes
chest pain
fast heartbeat
joint or muscle pain or stiffness
pounding heartbeat
severe stomach pain
difficulty breathing
tenderness inside the stomach area
unusual tiredness or weakness
Incidence mysterious
Area rash
black or tarry stools
bleeding gums
blistering, peeling, or loosening of the skin
blood within the stools
burning, numbness, tingling, or painful sensations
clay-colored stools
continuing vomiting
cough or hoarseness
dark urine
fever with or without chills
general a feeling of tiredness or weakness
high fever
large, hive-like swelling for the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
light-colored stools
back or side pain
pains in the stomach, side, or abdomen, possibly radiating towards the back
pale skin
pinpoint red spots on the skin
rapid, shallow breathing
red wounds, often with a purple center
red, irritated eyes
sores, ulcers, or white spots in the mouth or around the lips
swollen glands
unexplained bleeding or bruising
unpleasant breath odor
unsteadiness or awkwardness
unusual bleeding or bruising
upper right abdominal or stomach pain
vomiting of blood
weakness inside the arms, hands, legs, or feet

Some side effects may occur that always tend not to need medical help. These unwanted side effects may go away during treatment as the body adjusts on the medicine. Also, your overall health care professional may be able to tell you about approaches to prevent or reduce some of these negative effects. Check using your health care professional if any of the following side effects continue or are bothersome or if you've got any questions about them:
More common
Back pain
hair loss
skin rash
stomach pain
weight loss (unexplained)
Less common
decreased appetite
dry mouth
irritation or soreness from the mouth
itching of the skin
pain or burning inside throat
runny nose

Other unwanted side effects not listed could also exist in some patients. If you notice some other effects, check using your health care professional.

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It is critical that your physician check your progress at regular visits to make sure that this prescription medication is in working order. Blood tests may be required to check on for negative effects.

Using this medicine if you are pregnant can harm your developing fetus. Use an effective way of birth control to keep from conceiving a child. If you think you have conceive with the medicine, tell your physician without delay.

Leflunomide might also cause birth defects when the father is employing it when his sexual partner becomes pregnant. Men taking leflunomide should use condoms as a kind of birth control during sexual activity. A man going to father a young child should stop using this medicine and appearance together with his doctor right away.

Serious skin reactions can occur using this type of medicine. Stop employing this medicine and appearance with your medical professional without delay if you've got any in the following symptoms while using this medicine: blistering, peeling, or loosening in the skin; chills; itching; joint or muscle pain; red wounds, often with a purple center; sores, ulcers, or white spots in the mouth or for the lips; or unusual tiredness or weakness.

Liver problems may occur while you are choosing this medicine. Stop employing this medicine and check with a medical expert without delay in case you are having many of these symptoms: abdominal or stomach pain or tenderness; clay-colored stools; dark urine; decreased appetite; fever; headache; loss of appetite; queasiness; skin rash; swelling of the feet or legs; unusual tiredness or weakness; or yellow eyes or skin.

Leflunomide can temporarily lower the amount of white blood cells with your blood, enhancing the possibility of getting contamination. It can also lower the volume of platelets, which are needed for proper blood clotting. If this occurs, there are certain precautions you are able to take, specially when your blood count is low, to cut back the potential risk of infection or bleeding:

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Check with your physician right away if you've a cough with or without a fever, lack of breath, or any risk with breathing.

You needs to have a skin test for tuberculosis before starting by using this medicine. Tell your physician if you or anyone inside your home has ever had a positive response to a tuberculosis test.

Using this medicine may raise your probability of getting serious infections or cancer. Talk to your physician if you've concerns about it risk.

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Do not take other medicines unless to remain discussed with your medical professional. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamins.

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