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ARAVA is indicated in adults to the treating active rheumatism (RA):


Take this medicine only as directed by your doctor. Do not take more of it, don't take it often, and do not take on it much more time than a medical expert ordered.

The dose of the medicine changes for various patients. Follow a medical expert's orders or perhaps the directions for the label. The following information includes exactly the average doses of this medicine. If your dose differs, usually do not change it unless your medical professional informs you for this.

The level of medicine which you take depends for the strength of the medicine. Also, the quantity of doses you adopt daily, enough time allowed between doses, and the length of time you're taking the medicine depend on the problem that you can are employing the medicine.

For oral dosage form (tablets):

For arthritis rheumatoid:

If you miss a dose on this medicine, get it at the earliest opportunity. However, if it's almost time for your upcoming dose, skip the missed dose and get back on your regular dosing schedule. Do not double doses.


Store at 25°C (77°F); excursions able to 15-30°C (59-86°F). Protect from light. Keep out with the reach of youngsters. Do not keep outdated medicine or medicine don't needed. Store the medicine inside a closed container at room temperature, far from heat, moisture.

 Keep out with the reach of kids. Do not keep outdated medicine or medicine no more needed. Store the medicine in a very closed container at room temperature, faraway from heat, moisture.


Side Effects

Stop employing this medicine and check with a medical expert straight away if you are having burning, numbness, tingling, or painful sensations within the arms, hands, legs, or feet. These could be the signs of a condition called peripheral neuropathy.

Adverse reactions linked to the utilization of leflunomide in RA include diarrhea, elevated liver enzymes (ALT and AST), alopecia and rash.

Along having its needed effects, medicine may cause some unwanted side effects. Although not many of these side effects may occur, whenever they occur they could need medical attention.

Check with a medical expert immediately if any in the following side effects occur:
More common
Bloody or cloudy urine
difficult or painful breathing
difficult, burning, or painful urination
frequent urge to urinate
loss in appetite
nausea or vomiting
sore throat
tightness within the chest
yellow eyes or skin
Less common
Burning feeling within the chest or stomach
burning, prickling, or tingling sensation inside fingers or toes
chest pain
fast heartbeat
joint or muscle pain or stiffness
pounding heartbeat
severe stomach pain
lack of breath
tenderness in the stomach area
unusual tiredness or weakness
Incidence not known
Area rash
black or tarry stools
bleeding gums
blistering, peeling, or loosening of the skin
blood in the stools
burning, numbness, tingling, or painful sensations
clay-colored stools
continuing vomiting
cough or hoarseness
dark urine
fever with or without chills
general a feeling of tiredness or weakness
high fever
large, hive-like swelling for the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
light-colored stools
back or side pain
pains within the stomach, side, or abdomen, possibly radiating to the back
pale skin
pinpoint red spots around the skin
rapid, shallow breathing
red wounds, often having a purple center
red, irritated eyes
sores, ulcers, or white spots inside mouth or about the lips
swollen glands
unexplained bleeding or bruising
unpleasant breath odor
unsteadiness or awkwardness
unusual bleeding or bruising
upper right abdominal or stomach pain
vomiting of blood
weakness inside the arms, hands, legs, or feet

Some unwanted effects may occur have a tendency to usually do not need medical assistance. These negative effects may go away during treatment since your body adjusts on the medicine. Also, your overall health care professional may be able to share with you ways to prevent or reduce some unwanted effects. Check along with your health care professional if any of the following unwanted effects continue or are bothersome or if you've any queries about them:
More common
Back pain
hair loss
skin rash
stomach pain
weight loss (unexplained)
Less common
decreased appetite
dry mouth
irritation or soreness from the mouth
itching of the skin
pain or burning inside the throat
runny nose

Other unwanted effects unlisted might also happen in some patients. If you notice another effects, check along with your doctor.



It is vital that a medical expert check your progress at regular visits to make certain that this prescription medication is functional. Blood tests are usually necesary to evaluate for uncomfortable side effects.

Using this medicine when you are pregnant damages your developing fetus. Use an effective form of birth control to keep from conceiving. If you think you've got conceive with all the medicine, tell your medical professional right away.

Leflunomide could also cause birth defects if your father is applying it when his sexual partner becomes pregnant. Men taking leflunomide should use condoms as a type of birth control method during sex. A man intending to father a youngster should stop using this medicine and check with his doctor straight away.

Serious skin reactions can occur with this medicine. Stop employing this medicine and look with your medical professional straight away if you might have any from the following symptoms while using this medicine: blistering, peeling, or loosening of the skin; chills; itching; joint or muscle pain; red wounds, often with a purple center; sores, ulcers, or white spots in the mouth or around the lips; or unusual tiredness or weakness.

Liver problems may occur while you are employing this medicine. Stop applying this medicine and look with your physician immediately if you are having more than one of those symptoms: abdominal or stomach pain or tenderness; clay-colored stools; dark urine; decreased appetite; fever; headache; loss of appetite; feeling sick; skin rash; swelling of the feet or legs; unusual tiredness or weakness; or yellow eyes or skin.

Leflunomide can temporarily lower the volume of white blood cells within your blood, enhancing the chance of getting disease. It can also lower the amount of platelets, that are required for proper blood clotting. If this occurs, there are certain precautions you'll be able to take, particularly if your blood count is low, to relieve potential risk of infection or bleeding:

Check with your medical professional straight away if you have a cough with or without temperature, difficulty breathing, or any difficulty with breathing.

You will need to have a skin test for tuberculosis prior to starting by using this medicine. Tell your doctor if you or anyone inside your home has ever endured an optimistic reply to a tuberculosis test.

Using this medicine may raise your likelihood of getting serious infections or cancer. Talk to your physician if you've concerns about it risk.

Do not take other medicines unless they have been discussed with a medical expert. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamins.

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