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Uses

INDICATIONS

Chloroquine is indicated to the suppressive treatment as well as for acute attacks of malaria because of P. vivax, P.malariae, P. ovale, and susceptible strains of P. falciparum. The drug is also indicated to the management of extraintestinal amebiasis.

INSTRUCTIONS

Take chloroquine with meals or milk to lessen stomach upset, unless otherwise directed from your doctor.

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t is vital that you simply take chloroquine only as directed. Do not take a greater portion of it, don't take on it often, and do not take on it much more time than your physician ordered. To do so may increase the possibility of serious side effects.

If you take chloroquine to keep you against getting malaria, keep taking it for your full-time of treatment. If you have malaria, you must still keep taking chloroquine for that full time of treatment in case you start to feel great after a few days. This will help in order to the infection completely. If you stop taking chloroquine too quickly, your symptoms may return.

Chloroquine is ideal whenever you go on it on a regular schedule. For example, should you be to get it once a week in order to avoid malaria, it is advisable to take it on the same day every week. Or in case you are to consider two doses a day, one dose could be taken with breakfast and the other with the evening meal. Make sure that you don't miss any doses. If you've any queries relating to this, check with your quality of life care professional.

If you miss a dose of chloroquine, get it as soon as possible. However, if it is almost time for your forthcoming dose, skip the missed dose and return to your normal dosing schedule. Do not double doses.

DOSAGE 

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The dosage of chloroquine phosphate is frequently expressed in terms of equivalent chloroquine base. Each 500 mg tablet of ARALEN contains the same in principle as 300 mg chloroquine base. In infants and children the dosage is preferably calculated by body mass.

Malaria: Suppression - Adult Dose: 500 mg (= 300 mg base) on exactly the same day of weekly.

Pediatric Dose: The weekly suppressive dosage is 5 mg calculated as base, per kg of body weight, but shouldn't exceed the adult dose regardless of weight.

If circumstances permit, suppressive therapy should begin a couple weeks prior to exposure. However, failing this in adults, a preliminary double (loading) dose of 1 g (= 600 mg base), or perhaps children 10 mg base/kg could possibly be drawn in two divided doses, six hours apart. The suppressive therapy ought to be continued for 8 weeks after leaving the endemic area.
For Treatment of Acute Attack.

Adults: An initial dose of 1 g (= 600 mg base) accompanied by one more 500 mg (= 300 mg base) after six to eight hours along with a single dose of 500 mg (= 300 mg base) on everyone of two consecutive days. This represents an overall total dose of 2.5 g chloroquine phosphate or 1.5 g base in 3 days.

The dosage for adults of low body weight and then for infants and children needs to be determined as follows:

First dose: 10 mg base per kg (however, not exceeding just one dose of 600 mg base).

Second dose: (6 hours after first dose) 5 mg base per kg (however, not exceeding an individual dose of 300 mg base).

Third dose: (24 hours after first dose) 5 mg base per kg.

Fourth dose: (36 hours after first dose) 5 mg base per kg.

For radical cure of vivax and malariae malaria concomitant therapy having an 8-aminoquinoline compound is important.

Extraintestinal Amebiasis: Adults,1 g (600 mg base) daily for 2 days, then 500 mg (300 mg base) daily for around two or three weeks. Treatment is usually combined having an effective intestinal amebicide.

STORAGE 

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Store the medicine inside a closed container at room temperature, from heat, moisture, and direct light. Keep from freezing.

Keep out of your reach of children.

Do not keep outdated medicine or medicine don't needed.

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Side Effects

Along using its needed effects, medicine could cause some unwanted effects. Although not all of these side effects may occur, if they occur they could need medical help. When chloroquine is utilized for short durations, unwanted effects usually are rare. However, when it is employed for quite a long time and/or even in high doses, side effects are more inclined to occur and could be serious.

Check with your doctor immediately if any of these negative effects occur:
Less common

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Blurred vision
alteration of vision
eye pain
decrease of vision
Rare
Black, tarry stools
blood in urine or stools
convulsions (seizures)
cough or hoarseness
feeling faint or lightheaded
fever or chills
increased muscle weakness
lower back or side pain
mood and other mental changes
painful or difficult urination
pinpoint red spots on skin
ringing or buzzing in ears or any decrease of hearing
sore throat
unusual bleeding or bruising
unusual tiredness or weakness
Symptoms of overdose
Drowsiness
headache
increased excitability

Note: The negative effects within the Less Common category above may also occur or become worse when you stop taking chloroquine.

Some unwanted effects may occur have a tendency to don't need medical assistance. These unwanted effects might have to go away during treatment as the body adjusts for the medicine. Also, your overall health care professional could be able to share with you ways to prevent or reduce some of these unwanted side effects. Check with your overall health care professional if these things unwanted side effects continue or are bothersome or if you might have questions about them:


More common


Diarrhea
difficulty in seeing to read
headache
itching (more widespread in black patients)
loss in appetite
nausea or vomiting
stomach cramps or pain
Less common
Bleaching of hair or increased hair loss
blue-black discoloration of skin, fingernails, or inside of mouth
skin rash

Other side effects not listed may also exist in some patients. If you notice any other effects, seek advice from your doctor.

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Precautions

If you'll be taking chloroquine for quite a long time, it is vital that your doctor check you at regular visits for almost any blood problems or muscle weakness that may be caused by chloroquine. In addition, talk with your physician immediately if blurred vision, difficulty in reading, or some other change in vision occurs during or after treatment. Your doctor may wish that you have the eyes checked by an ophthalmologist (eye doctor).

If your symptoms usually do not improve in just a few days or when they become worse, check with a medical expert.

Make sure you understand how you respond to chloroquine before you decide to drive, use machines, or do anything else that is dangerous should you be not able to see well.

Chloroquine could cause blurred vision, difficulty in reading, or another change in vision. It could also cause some people being lightheaded.

If these reactions are specially bothersome, check with your medical professional.

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Certain medicines shouldn't be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines might also cause interactions to take place. Discuss along with your healthcare professional using your medicine with food, alcohol, or tobacco.

There are no adequate and well-controlled studies evaluating the protection and efficacy of chloroquine in expectant women. Usage of chloroquine in pregnancy ought to be avoided except within the suppression or treating malaria when inside judgment of the physician the benefit outweighs the possibility risk towards the fetus.

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