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See also Warning section.

This medicine is used to treat mental/mood that is certain (schizophrenia, schizoaffective disorders). Clozapine is a medication that is psychiatricanti-psychotic type) that works by helping to restore the balance of particular natural substances (neurotransmitters) within the brain.

Clozapine decreases hallucinations and aids in preventing suicide in people who tend to use to harm themselves. It can help you to definitely think more clearly and positively about your self, feel less nervous, and indulge in everyday life.

Utilizing Clozaril

If you are utilizing the liquid form with this medication, read the Patient Suggestions Leaflet if available from your pharmacist before you begin taking clozapine and each time you get a refill. If you have any relevant questions, pose a question to your doctor or pharmacist.

Take this medication by mouth with or without food, as directed by your doctor. If you're taking the pills that dissolve in the lips, remove each tablet carefully from the blister pack immediately before taking your dose. Allow the tablets to dissolve on your tongue and swallow. There is no need to take the dissolving tablets with water. Discard any dissolving tablets that have been previously exposed to air due to packaging that is opened/damaged. Do not save them for your next dose.

If you work with the form that is liquid of medication, shake the bottle well for 10 seconds before each use. Carefully measure the dose using a special measuring device/spoon. Don't use a household spoon because you may not get the correct dose.

It is critical to begin to take this drug at a low dose, increasing your dose slowly, to lessen adverse effects such as dizziness, drowsiness and seizures. Follow your doctor's instructions exactly. Your dosage is based on your condition that is medical and to therapy. Since clozapine can cause a decrease in white blood cells, you will need to get blood tests done regularly as directed. Be sure to keep all appointments for these laboratory tests. (See also Notes section.)

You were on (see Missed Dose section) if you miss your doses for longer than a day or two, consult your doctor for a new schedule to get back to the dose. Use this medication regularly in order to get the benefit that is most from this. To simply help you keep in mind, use it at the time( that is same) each day.

Do not stop taking clozapine without consulting your doctor. Some conditions may become worse when the drug is suddenly stopped. Also, you may experience symptoms such as severe sweating, headache, nausea, vomiting, and diarrhea. To avoid these signs while you're stopping treatment with this drug, your physician may reduce your dosage slowly. Check with your doctor or pharmacist for more details. Report any new or symptoms that are worsening away.

It might take weeks prior to the full benefit of this medication takes effect. Inform your physician if for example the condition persists or worsens.

Side Effects

See also Warning section.

Drooling, drowsiness, dizziness, headache, shaking (tremor), vision problems (e.g., blurred vision), weight gain, and constipation may occur. Many of these effects (especially drowsiness) lessen as your body gets used to the medication. If any of these effects persist or worsen, contact your pharmacist or doctor immediately.

To prevent constipation, maintain a meal plan adequate in fiber, drink plenty of water, and workout. If you feel constipated while using the this drug, consult with your pharmacist for help in selecting a laxative (age.g., stimulant-type with stool softener).

Keep in mind that your doctor has prescribed this medication she has judged that the benefit to you is greater than the risk of side effects because he or. Many people using this medication do not have serious adverse effects.

This medication may rarely make your blood sugar level rise, which can cause or worsen diabetes. Rarely, very serious conditions such as diabetic coma may occur. Tell your medical practitioner right away if you develop symptoms of high blood sugar levels, such as increased thirst and urination. If you already have diabetic issues, be sure to check your blood sugars regularly. Your medical professional may need to adjust your diabetes medication, exercise program, or diet.

This drug could also cause weight that is significant and a growth in your cholesterol (or triglyceride) levels. These effects, along with diabetic issues, may increase your risk for developing heart infection. Discuss the risks and benefits of treatment with your physician.

Tell your physician right away if you have any serious side effects, including: facial/muscle twitching, seizures, uncontrollable motions.

Get medical help right away if you have really serious part results, including: severe dizziness, fainting, mental/mood changes, difficulty respiration with exercise, sudden weakness, pain/redness/swelling of the arms/legs, persistent nausea/vomiting, stomach/abdominal pain, yellowing of eyes/skin.

This medicine may rarely cause a very serious condition called neuroleptic malignant syndrome (NMS). Get medical help right away if you have any associated with the following symptoms: fever, muscle mass stiffness/pain/tenderness/weakness, serious tiredness, severe confusion, sweating, fast/irregular heartbeat, dark urine, change in the amount of urine.

A tremendously serious reaction that is allergic this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious reaction that is allergic include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is simply not a list that is complete of side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about part results. You may report effects that are side Food And Drug Administration at 1-800-FDA-1088 or at

In Canada - Call your doctor for medical advice about side effects. You may report adverse effects to Health Canada at 1-866-234-2345.


See also Warning and adverse Effects parts.

Before using clozapine, tell your doctor or pharmacist in the event that you are allergic to it or if you have any other allergies. This product may contain inactive ingredients, which trigger allergy symptoms or other dilemmas. Talk to your pharmacist for additional information.

Before using this medication, tell your medical practitioner or pharmacist your medical history, especially of: history of blood disorders (such as for example leukemia, low blood that is white count), bowel problems (such as paralytic ileus, cranky bowel syndrome ), difficulty in breathing, diabetes/family history of diabetes, high cholesterol/triglyceride levels, glaucoma, heart problems, renal problems, liver problems, obesity/family history of obesity, seizures, trouble urinating (such as prostate problems).

Clozapine may cause a condition that affects one's heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other signs (such as serious dizziness, fainting) that require medical attention right away.

The risk of QT prolongation may be increased for those who have specific medical conditions or are taking other drugs that will influence one's heart rhythm. Before using clozapine, tell your physician or pharmacist of all the drugs you take and when you have some of the following conditions: certain heart dilemmas (heart failure, sluggish heartbeat, QT prolongation into the EKG), genealogy and family history of certain heart disease (QT prolongation into the EKG, sudden cardiac death).

Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/"water pills") or if you have conditions such as severe sweating, diarrhea, or vomiting. Talk to your doctor about utilizing clozapine safely.

This drug may make you dizzy or drowsy or cause blurred vision. Do not drive, use machinery, or do any activity that requires alertness or clear vision you can perform such activities safely until you are sure. Limit alcoholic beverages.

Tell your physician if you are a descendent of Ashkenazi Jews because you may be at a higher risk for a drop in your white blood cells.

Before having surgery, tell your dentist or doctor that you're using this medicine.

Liquid products or tablets that are dissolving contain sugar and/or aspartame. Liquid products may also contain alcohol. Caution is encouraged if you have diabetes, liver disease, phenylketonuria (PKU), or any other condition that requires you to limit/avoid these substances in your diet. Ask your doctor or pharmacist about using this product safely.

Older adults may be more responsive to the relative part aftereffects of this drug, particularly constipation, dizziness, and QT prolongation (see above). Dizziness can boost the danger of falling.

During maternity, this medicine should be used only when obviously needed. Babies born to mothers who have used this drug during the last 3 months of pregnancy may rarely develop symptoms including muscle stiffness or shakiness, drowsiness, feeding/breathing difficulties, or constant crying. If you notice any of these symptoms in your newborn especially during their month that is first the doctor right away.

Since untreated mental/mood issues (such as for example schizophrenia, schizoaffective disorders) can be a condition that is serious do not stop taking this medication unless directed by your doctor. You may be pregnant, immediately discuss with your doctor the benefits and risks of using this medication during pregnancy if you are planning pregnancy, become pregnant, or think.

This medicine may pass into breast milk and now have undesirable effects on a nursing infant. Breast feeding is not advised while taking clozapine. Consult your medical practitioner before breast-feeding.

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