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Precautions

Do NOT use Depakote if:

• you are allergic to any ingredient in Depakote
• you might have liver problems or a urea cycle disorder.

Contact your physician or health care provider immediately if these affect you.

Some medical conditions may connect to Depakote. Tell a medical expert or pharmacist in case you have any medical ailments, particularly if any of the following connect with you:

• if you happen to be pregnant, likely to get pregnant, are breast-feeding
• in case you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• in case you have a history of irresponsible drinking, liver problems, metabolic disease, blood disease, HIV infection, cytomegalovirus (CMV) infection, high blood numbers of ammonia or glutamine, low body's temperature, low levels of albumin, brain problems (eg, organic brain disease), mental retardation, inflammation of the pancreas, kidney problems, or low amounts of white blood cells, or if you are scheduled for surgery
• for those who have a reputation ornithine transcarbamylase deficiency or unexplained coma
• when you have a family reputation urea cycle disorders or unexplained infant deaths
• when you have a reputation mental or mood problems (eg, depression), or suicidal thoughts or actions
• if you're taking another medicine for seizures.

Some medicines may communicate with Depakote. Tell your medical provider in the event you consider some other medicines, especially any from the following:

• Benzodiazepines (eg, diazepam), carbamazepine, erythromycin, felbamate, fluoxetine, guanfacine, isoniazid, ketoconazole, risperidone, or salicylates (eg, aspirin) for the reason that chance of serious unwanted effects of Depakote, including modifications in vision or another vision problems, clumsiness or unsteadiness, drowsiness, nausea, or vomiting, could possibly be increased
• Clonazepam as the likelihood of seizures could possibly be increased
• Topiramate for the reason that likelihood of high ammonium levels, brain problems, or an unusual drop in body temperature might be increased
• Acyclovir, cancer medicines, carbapenem antibiotics (eg, ertapenem, imipenem, meropenem), cholestyramine, hydantoins (eg, phenytoin), mefloquine, nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), oral contraceptives (eg, contraception pills), or rifampin because they may decrease Depakote's effectiveness
• Anticoagulants (eg, warfarin), barbiturates (eg, phenobarbital), ethosuximide, lamotrigine, methylphenidate, primidone, tolbutamide, tricyclic antidepressants (eg, amitriptyline), or zidovudine because the risk of their unwanted side effects could be increased by Depakote.

This is probably not a complete report on all interactions which could occur. Ask your doctor if Depakote may connect to other medicines that you adopt. Check with your health care provider before you begin, stop, or affect the dose associated with a medicine.

Important safety information:

• Depakote could cause drowsiness, dizziness, or blurred vision. These effects may be worse in case you get it with alcohol or certain medicines. Use Depakote with caution. Do not drive or perform other possible unsafe tasks unless you discover how you respond to it.
• Do not consume alcohol or use medicines that could cause drowsiness (eg, sleep aids, muscle relaxers) while you're using Depakote; it could enhance their effects. Ask your friendly phamacist in case you have queries about which medicines could cause drowsiness.
• Inflammation of the pancreas is really a potentially life-threatening illness connected with Depakote. Symptoms include stomach pain, vomiting, or lack of appetite. Contact your medical professional immediately if any of these symptoms occur.
• Patients having Depakote could possibly be at increased risk for suicidal thoughts or actions. The risk might be greater in patients who have had suicidal thoughts or actions inside past. Patients who've bipolar (manic-depressive) illness may also provide an increased risk for suicidal thoughts or actions. Watch patients who take Depakote closely. Contact a doctor at the same time if new, worsened, or sudden symptoms, for example depressed mood; anxious, restless, irritable behavior; panic disorder; or any unusual alternation in mood or behavior occur. Contact a doctor without delay if any signs and symptoms of suicidal thoughts or actions occur.
• Depakote may slow up the variety of clot-forming cells (platelets) within your blood. Avoid activities that may cause bruising or injury. Tell a medical expert for those who have unusual bruising or bleeding. Tell your doctor when you have dark, tarry, or bloody stools.
• Tell your physician or dentist that you adopt Depakote prior to deciding to have any medical or dentistry, emergency care, or surgery.
• Diabetes patients - Depakote could cause the outcome of some tests for urine ketones being wrong. Ask your doctor when you change your diet or the dose of one's diabetes medicine.
• Depakote could raise the ammonia levels in your blood. Contact your physician without delay should you experience unexplained sluggishness and vomiting or mental changes.
• Depakote could cause an unusual drop in temperature (hypothermia). Symptoms might include confusion, deficiency of energy, decrease of coordination, shivering, slow heartbeat, slow or shallow breathing, slurred speech, or unusual drowsiness. Contact your physician right away for those who have all of these symptoms.
• Depakote may hinder certain lab tests, including thyroid function. Be sure a medical expert and lab personnel know you take Depakote
• Lab tests, including complete blood cell counts, blood ammonia levels, and liver function, might be performed as you use Depakote. These tests might be accustomed to monitor your problem or pay attention to unwanted effects. Be sure to keep all doctor and lab appointments.
• Use Depakote with caution inside elderly; they could be more responsive to its effects, especially drowsiness.
• Depakote must be used in combination with extreme caution in kids younger than a decade old; safety and effectiveness during these children weren't confirmed. Children younger 2 years may be at increased likelihood of serious liver problems.
• Pregnancy and breast-feeding: Depakote has been shown to damage the fetus. Use an effective way of birth control method while you adopt Depakote. If you think you could be pregnant or in the event you wish to conceive, contact your doctor. You will need to discuss the benefits and perils of using Depakote if you are pregnant. Depakote is found in breast milk. Do not breastfeed while you're taking Depakote.