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• for those who have a reputation irresponsible drinking, liver problems, metabolic disease, blood disease, HIV infection, cytomegalovirus (CMV) infection, high blood degrees of ammonia or glutamine, low temperature, low numbers of albumin, brain problems (eg, organic brain disease), mental retardation, inflammation with the pancreas, kidney problems, or low degrees of white blood cells, or if you might be scheduled for surgery

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Some medicines may connect to Depakote. Tell your doctor if you are taking some other medicines, especially any from the following:

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• Benzodiazepines (eg, diazepam), carbamazepine, erythromycin, felbamate, fluoxetine, guanfacine, isoniazid, ketoconazole, risperidone, or salicylates (eg, aspirin) because the likelihood of serious unwanted effects of Depakote, including modifications in vision or another vision problems, clumsiness or unsteadiness, drowsiness, nausea, or vomiting, could be increased

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• Acyclovir, cancer medicines, carbapenem antibiotics (eg, ertapenem, imipenem, meropenem), cholestyramine, hydantoins (eg, phenytoin), mefloquine, nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), oral contraceptives (eg, birth control pills), or rifampin since they may decrease Depakote's effectiveness

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• Anticoagulants (eg, warfarin), barbiturates (eg, phenobarbital), ethosuximide, lamotrigine, methylphenidate, primidone, tolbutamide, tricyclic antidepressants (eg, amitriptyline), or zidovudine since the likelihood of their unwanted side effects could be increased by Depakote.

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Important safety information:

• Depakote may cause drowsiness, dizziness, or blurred vision. These effects could be worse should you go on it with alcohol or certain medicines. Use Depakote with caution. Do not drive or perform other possible unsafe tasks and soon you understand how you respond to it.

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• Do not are drinking alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) if you are using Depakote; it could help to increase their effects. Ask the pharmacist for those who have questions on which medicines could cause drowsiness.

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• Depakote may reduce the variety of clot-forming cells (platelets) with your blood. Avoid activities that could potentially cause bruising or injury. Tell a medical expert in case you have unusual bruising or bleeding. Tell your medical professional when you have dark, tarry, or bloody stools.

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• Depakote might cause a silly drop in body temperature (hypothermia). Symptoms can include confusion, deficiency of energy, loss in coordination, shivering, slow heartbeat, slow or shallow breathing, slurred speech, or unusual drowsiness. Contact your physician without delay when you have some of these symptoms.

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• Depakote may hinder certain lab tests, including thyroid function. Be sure a medical expert and lab personnel know you take Depakote

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• Lab tests, including complete blood cell counts, blood ammonia levels, and liver function, could possibly be performed while you use Depakote. These tests could possibly be employed to monitor your complaint or search for unwanted side effects. Be sure to keep all doctor and lab appointments.

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• Depakote needs to be in combination with careful attention in children younger than a decade old; safety and effectiveness over these children weren't confirmed. Children younger two years could possibly be at increased risk of serious liver problems.

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