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Precautions

Do NOT use Duetact if:

• you're allergic to any ingredient in Duetact
• you might have moderate to severe heart failure, liver problems or abnormal liver function tests, certain severe problems related to diabetes (eg, diabetic ketoacidosis, diabetic coma), moderate to severe burns, or very high blood acid levels (acidosis)
• you have type 1 diabetes
• you consider bosentan.

Contact a medical expert or doctor right away if these apply to you.

Some medical ailments may communicate with Duetact. Tell a medical expert or pharmacist in case you have any health concerns, especially if any from the following connect with you:

• if you're pregnant, likely to become pregnant, or are breast-feeding
• in the event you take any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or any other substances
• for those who have had a serious hypersensitive reaction (eg, severe rash, hives, , etc ., dizziness) to the other sulfonamide medicine including acetazolamide, celecoxib, certain diuretics (eg, hydrochlorothiazide), glipizide, probenecid, sulfamethoxazole, valdecoxib, or zonisamide
• for those who have a history of kidney, thyroid, heart, or circulatory problems; anemia, stroke; certain hormonal problems (eg, adrenal or pituitary problems, syndrome of inappropriate secretion of antidiuretic hormone [SIADH]); low blood sodium levels; or 'abnormal' amounts of your enzyme called glucose 6-phosphate dehydrogenase (G6PD)
• for those who have stomach or bowel problems (eg, stomach or bowel blockage, stomach paralysis), consume alcohol, or have had poor nutrition
• in case you have very poor health, a high fever, an extreme infection, severe diarrhea, high blood acid levels, or brain or nerves problems, or have had a severe injury
• if you have a history of bladder cancer, bone fracture, low calcium intake, or weak bones (eg, osteoporosis)
• when you have swelling problems (edema) or certain eye problems (macular edema)
• if you may be having surgery.

Some medicines may connect to Duetact. Tell your doctor if you are taking any other medicines, especially any with the following:

• Bosentan because liver problems may occur, along with the effectiveness of both medicines could be decreased
• Beta-blockers (eg, propranolol) since the likelihood of low blood glucose levels may be increased. They may also hide certain warning signs of low blood sugar levels and make it more challenging to notice
• Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), azole antifungals (eg, miconazole, ketoconazole), chloramphenicol, clarithromycin, clofibrate, disopyramide, fenfluramine, fluoxetine, insulin, monoamine oxidase inhibitors (MAOIs) (eg, phenelzine), nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), phenylbutazone, probenecid, quinolone antibiotics (eg, ciprofloxacin), salicylates (eg, aspirin), and sulfonamides (eg, sulfamethoxazole) because the risk of low blood sugar levels could be increased
• Calcium channel blockers (eg, diltiazem), corticosteroids (eg, prednisone), decongestants (eg, pseudoephedrine), diazoxide, diuretics (eg, furosemide, hydrochlorothiazide), estrogens, hormonal contraceptives (eg, contraception pills), isoniazid, niacin, phenothiazines (eg, promethazine), phenytoin, rifamycins (eg, rifampin), sympathomimetics (eg, albuterol, epinephrine), or thyroid supplements (eg, levothyroxine) because they may decrease Duetact's effectiveness, resulting in high blood sugar levels
• Gemfibrozil because blood glucose levels might be increased or decreased
• Anticoagulants (eg, warfarin) as their effectiveness could be decreased or the chance of their negative effects might be increased by Duetact.

This might not be a total list of all interactions which could occur. Ask your doctor if Duetact may communicate with other medicines which you take. Check with your doctor before you begin, stop, or alter the dose of any medicine.

Important safety information:

• Duetact might cause drowsiness, dizziness, blurred vision, or lightheadedness. These effects may be worse if you go with alcohol or certain medicines. Use Duetact with caution. Do not drive or perform other possible unsafe tasks unless you understand how you respond to it.
• Do not are drinking alcohol while you consider Duetact; it may well boost the chance of low blood glucose. Rarely, alcohol may talk with Duetact and cause a serious reaction with symptoms like flushing, nausea, vomiting, dizziness, or stomach pain. Discuss questions or concerns together with your doctor.
• Carry an ID card all the time that says you've diabetes.
• Proper dieting and exercise are crucial as a way to lose weight whilst it well. Follow the eating and working out program provided to you because of your health care provider.
• Check your blood sugar levels as directed through your doctor. If they are often higher or below they should be so you take Duetact exactly as prescribed, tell your doctor.
• It might be harder to regulate your blood sugar levels during times of stress including fever, infection, injury, or surgery. Talk together with your doctor about how exactly to manipulate your blood glucose levels if any of these occur. Do not alter the dose of your respective medicine without checking using your doctor.
• Do not take more than the recommended dose without checking using your doctor.
• Duetact may cause low blood sugar levels levels. Low blood glucose may make you anxious, sweaty, weak, dizzy, drowsy, or faint. It may also build your heartbeat faster; help make your vision change; give you a headache, chills, or tremors; or cause you to be more hungry. It is really a good option to hold a dependable supply of glucose (eg, tablets or gel) to deal with low blood sugar. If this is not available, you ought to eat or drink a fast way to obtain sugar like countertop sugar, honey, candy, orange juice, or non-diet soda. This will raise your blood glucose levels level quickly. Tell a medical expert right away in such a circumstance. To prevent low blood glucose, eat meals concurrently every day and never skip meals.
• Risk of low blood sugar levels may be increased by severe or prolonged exercise, having a drink, or skipping meals.
• Duetact has a sulfonylurea. It may increase the risk of death from coronary disease. Talk with your doctor in regards to the benefits and perils of this or another therapies to take care of your trouble.
• Duetact could potentially cause ovulation in ladies that have not reached menopause but don't ovulate. To avoid pregnancy, be sure to utilize effective birth control while using the Duetact.
• Duetact might cause you to become sunburned quicker. Avoid the sun, sunlamps, or tanning booths until you know how you answer Duetact. Use a sunscreen or wear protective clothing in case you must be outside for a lot more than a small amount of time.
• Tell a medical expert or dentist which you take Duetact when you receive any medical or dentistry, emergency care, or surgery.
• Duetact might be related to an increased probability of bladder cancer. Discuss questions or concerns along with your doctor.
• An increased incidence of bone fracture has been reported ladies who take Duetact. Tell your doctor when you have a history of bone fracture, low calcium intake, or weak bones (eg, osteoporosis). Tell your physician immediately in case you experience any unusual bone pain.
• Lab tests, including fasting blood glucose levels, hemoglobin A_1c, liver function, and eye exams, might be performed when you use Duetact. These tests may be used to monitor your trouble or pay attention to side effects. Be sure to keep all doctor and lab appointments.
• Use Duetact with caution inside elderly; they may be more responsive to its effects, particularly the chance of heart problems or low blood glucose.
• Duetact really should not be found in children; safety and effectiveness in children are not confirmed.
• Pregnancy and breast-feeding: Duetact could cause trouble for the fetus or newborn. If you think you could be pregnant, speak to your doctor. You will need to discuss the huge benefits and perils associated with using Duetact while you are pregnant. It is not known if Duetact is located in breast milk. Do not breastfeed while taking Duetact.

When used by a long Duetact may well not act as well. If your blood glucose levels may be in check after which becomes tough to manage, get hold of your doctor. Do not affect the dose of the medicine without checking together with your doctor.