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Uses

INDICATIONS

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Indinavir can be an antiviral medication in a number of HIV medicines called protease (PRO-tee-ayz) inhibitors. Indinavir prevents human immunodeficiency virus (HIV) cells from multiplying within you. It is employed to treat HIV, that causes acquired immunodeficiency syndrome (AIDS). Indinavir is not a cure for HIV or AIDS.

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INSTRUCTIONS

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Take indinavir just as it absolutely was prescribed for you personally. Do not consider the medication in larger amounts, or get it more than recommended because of your doctor. Follow the directions in your prescription label.

This medication is sold with patient instructions for secure and efficient use. Follow these directions carefully. Ask your physician or pharmacist for those who have any queries.
Take indinavir having a full glass (8 ounces) of water or skim milk. You could also drink juice, coffee, or tea using this type of medication. Drink at the very least 6 servings of water each day in order to avoid kidney stones if you are taking indinavir. Indinavir should be taken on jail stomach, at the very least an hour before or couple of hours after having a meal.

If you want to consider the medication with food, eat just a light meal, including dry toast with jelly, or corn flakes with skim milk and sugar. Avoid eating a high-fat meal.

It is essential to work with indinavir regularly to have the most benefit. Get your prescription refilled before you run out of medicine completely.

To make sure this medication is assisting your condition, your blood should be tested frequently. Your liver function can also have to be tested. Do not miss any scheduled visits to a medical expert.

HIV/AIDS is often treated having a combination of different drugs. To best treat your problem, utilise all of the medications as directed because of your doctor. Be sure to see the medication guide or patient instructions supplied with each of one's medications. Do not alter your doses or medication schedule without advice from your physician. Every person with HIV or AIDS should remain under the proper a physician.

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Take the missed dose as soon as you remember and take the next dose with the regularly scheduled time. If you are a lot more than couple of hours late in taking your indinavir, skip the missed dose and make next regularly scheduled dose. Do not take extra medicine to create inside the missed dose.

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DOSAGE

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Usual Adult Dose for HIV Infection
800 mg orally every 8 hours or indinavir 800 mg plus ritonavir 100 mg to 200 mg orally every 12 hours.

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Usual Adult Dose for Nonoccupational Exposure
800 mg orally every 8 hours or indinavir 800 mg plus ritonavir 100 mg to 200 mg orally every 12 hours.
Duration: Prophylaxis needs to be initiated as quickly as possible, within 72 hours of exposure, and continued for 28 days.
Indinavir plus ritonavir plus 2 NRTIs is one of the alternative regimens recommended for nonoccupational postexposure HIV prophylaxis.

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Usual Adult Dose for Occupational Exposure
800 mg orally every 8 hours 800 mg orally every 8 hours plus lamivudine-zidovudine,
or indinavir 800 mg plus ritonavir 100 mg to 200 mg orally every 12 hours plus lamivudine-zidovudine.
Duration: Therapy should start promptly, preferably within 1 to 2 hours postexposure. The exact amount of therapy may vary based on the institution's protocol.

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Liver Dose Adjustments
Mild to moderate hepatic insufficiency: 600 mg orally every 8 hours.

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Dose Adjustments
Consider reducing the dose to 600 mg every 8 hours if delavirdine, itraconazole, or ketoconazole are administered concomitantly. Increase the dose to 1000 mg every 8 hours if rifabutin emerged concurrently, and decrease the rifabutin dose by half.
Precautions

Strict adherence on the prescribed dose is essential. Patients shouldn't affect the dose or discontinue therapy without talking to their physician.

Adequate hydration (1.5 liters/day) is essential during therapy to lessen the risk of nephrolithiasis. A brief interruption (usually 1 to 3 days) or total discontinuation might be necessary if nephrolithiasis occurs.

Discontinue indinavir if hemolytic anemia occurs. Consider discontinuation if severe leukocyturia develops.

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STORAGE

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Store indinavir at room temperature faraway from moisture and warmth. Keep the capsules inside their original container, along with the packet of moisture-absorbing preservative that includes indinavir capsules.

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Side Effects

Get emergency medical help when you have some of these warning signs of a hypersensitivity: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop taking indinavir and call your physician simultaneously in case you have some of these serious unwanted side effects:

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Less serious unwanted side effects can include:

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This isn't a complete report on unwanted side effects and others may occur. Tell a medical expert about any unusual or bothersome complication.

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Precautions

Do not take prescription drugs in case you are allergic to indinavir.
Do not take indinavir with amiodarone (Cordarone, Pacerone), cisapride (Propulsid), pimozide (Orap), alprazolam (Xanax), oral midazolam (Versed), triazolam (Halcion), or ergot medicines such as ergotamine (Ergomar, Cafergot), dihydroergotamine (D.H.E. 45, Migranal Nasal Spray), ergonovine (Ergotrate), or methylergonovine (Methergine). These drugs may cause life-threatening unwanted effects if you are using them if you are taking indinavir.

Before taking indinavir, tell your doctor if you're allergic to the drugs, or if you have:

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If you have these conditions, you need a dose adjustment or special tests to securely take indinavir.
FDA pregnancy category C. This medication could be damaging to an unborn baby. Tell your medical professional in case you are pregnant or want to conceive during treatment. HIV can be passed on the baby if your mother just isn't properly treated in pregnancy. Take all of one's HIV medicines as given to moderate your infection if you are pregnant.

Your name may have to be from an antiviral pregnancy registry once you begin using medicines.
You should not breast-feed when you are using indinavir. Women with HIV or AIDS ought not breast-feed in any respect. Even if your baby is born without HIV, you might still pass the virus on the baby within your breast milk.

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