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Mestinon (Pyridostigmine) affects chemicals in the body which can be active in the communication between nerve impulses and muscle movement.

Pyridostigmine is utilized to help remedy the the signs of myasthenia gravis. It is also utilized in military personnel who had been exposed to nerve gas.

Pyridostigmine could also be used for purposes unlisted with this medication guide.


Take the same manner prescribed by your doctor. Do not take in larger or smaller amounts and more than recommended. Follow the directions on your prescription label.
Take this medicine with food or milk whether it upsets your stomach. Do not crush, chew, or break an extended-release tablet. Swallow it whole. Breaking or opening the pill may cause excessive drug to be released at one time.

Measure liquid medicine using a special dose measuring spoon or medicine cup, not having a regular table spoon. If you do not use a dose measuring device, ask the pharmacist for just one.

The amount and timing with this drugs are vitally important for the success of the treatment. Carefully follow your doctor's instructions about how exactly much medicine to look at when to adopt it.

Your doctor may occasionally improve your dose to successfully acquire the best results. You may be motivated to keep a daily record of once you took each dose and how long the consequences lasted. This will help a medical expert see whether your dose needs to be adjusted.
If you need surgery, tell the surgeon beforehand that you are using pyridostigmine. You may need to stop with all the medicine for any short time. Store at room temperature faraway from moisture and warmth.


Take the medicine as prescribed through your doctor.


Keep the tablets of their original container, with the canister of moisture-absorbing preservative that accompanies this medicine.


Active ingredient: Pyridostigmine

Side Effects

Get emergency medical help if you have any of these signs of a hypersensitivity: hives; lack of breath; swelling of your respective face, lips, tongue, or throat. Stop using pyridostigmine and call your medical professional at the same time in case you have some of these serious negative effects:

extreme muscle weakness, muscle twicthing;

slurred speech, vision problems;

severe vomiting or diarrhea;

cough with mucus;

confusion, anxiety, panic disorder;

seizure (convulsions); or

worsening or no improvement with your signs of myasthenia gravis.

Less serious unwanted side effects can include:

cold sweat, pale skin;

urinating more than usual;

watery eyes;

mild nausea, vomiting, or upset stomach;

warmth or tingly feeling; or

mild rash or itching.

This is not a complete set of side effects and others may occur. Call your physician for health advice about unwanted effects.


You should avoid using pyridostigmine in case you are allergic to it, or if you have a very bladder or bowel obstruction.

To ensure you can safely take pyridostigmine, tell your physician for those who have these other difficulties:


kidney disease;

an ulcer and other serious stomach disorder;

high blood pressure levels, cardiovascular disease;

overactive thyroid; or

a good reputation for seizures.

It just isn't known whether pyridostigmine will harm an child. Tell your medical professional if you're pregnant or prefer to get pregnant when using medicines. It isn't known whether pyridostigmine passes into breast milk or if it could harm a nursing baby. Do not use prescription drugs without telling a medical expert if you are breast-feeding an infant.

Drugs interaction 

Tell your medical professional about other medicines you employ, especially:

atropine (Atreza, Sal-Tropine);

belladonna (Donnatal, while others);

benztropine (Cogentin);

clidinium (Quarzan);

clozapine (Clozaril, FazaClo);

dimenhydrinate (Dramamine);

methscopolamine (Pamine), scopolamine (Transderm Scop);

glycopyrrolate (Robinul);

mepenzolate (Cantil);

bladder or urinary medications for example darifenacin (Enablex), flavoxate (Urispas), oxybutynin (Ditropan, Oxytrol), tolterodine (Detrol), or solifenacin (Vesicare);

bronchodilators for example ipratropium (Atrovent) or tiotropium (Spiriva);

cold medicine, allergy medicine, or sleeping pills which contain an antihistamine including diphenhydramine (Tylenol PM) or doxylamine (Unisom);

heart rhythm medication such as quinidine (Quin-G), procainamide (Procan, Pronestyl), disopyramide (Norpace), flecaininde (Tambocor), mexiletine (Mexitil), propafenone, (Rythmol), among others;

irritable bowel medications like dicyclomine (Bentyl), hyoscyamine (Hyomax), or propantheline (Pro Banthine);

medicine to treat Alzheimer's dementia, like donepezil (Aricept), rivastigmine (Exelon), or tacrine (Cognex); or

a steroid for example betamethasone (Celestone) or dexamethasone (Cortastat, Dexasone, Solurex, DexPak).

This list isn't complete along with other drugs may interact with pyridostigmine. Tell your doctor about all medications you utilize. This includes prescription, over-the-counter, vitamin, and herbal products. Do not begin a new medication without telling your medical professional.

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