Generic Motilium is used to supress sickness and vomiting, and works primarily by blocking dopamine receptors found in the upper end of the digestive system. This causes tightening of the muscles at the entry to the stomach, relaxation of the muscles at the exit of the stomach and increased contraction of the muscles in the stomach itself. These actions speed up the passage of food through the stomach into the intestine, which physically helps prevent vomiting and reduces feelings of sickness, bloating and fullness. It also prevents food from flowing the wrong way through the stomach and so prevents reflux (regurgitation of the stomach contents right back into the foodpipe).
Side-effects consist of:
Since domperidone is highly metabolised in the liver, domperidone should be used with caution in patients with hepatic impairment (and in the elderly).
Domperidone should really be used with caution in patients with renal impairment or in those at threat of water retention. In patients with serious renal insufficiency (serum creatinine more than 6mg/100ml, i.e. more than 0,6mmol/L) the elimination half-life of domperidone was increased from 7,4 to 20,8 hours. The dosing frequency should be reduced to once or twice daily, with respect to the severity of impairment, and the dosage may need to be paid down. Patients on prolonged therapy should be reviewed regularly.
Airmail: 2-3 weeks, EMS: 3-8 business days.