This medication is used to deal with despair. It is also used with other therapies for the treatment of nighttime bed-wetting (enuresis) in young ones. Using this medication to deal with depression may boost your mood, rest, appetite, and energy level and could help restore your fascination with daily living. Imipramine might help your youngster control nighttime bed-wetting.

Imipramine belongs to a class of medicines called tricyclic antidepressants. It works by restoring the balance of certain substances that are naturalneurotransmitters such as norepinephrine) in the brain. For bed-wetting, this medication may work by blocking the impact of a certain natural substance (acetylcholine) on the bladder.

DIFFERENT USES: This section contains uses of this drug that aren't detailed in the approved professional labeling for the drug but that may be prescribed by your quality of life care expert. Make use of this drug for a condition that is listed in this section only if it has been so prescribed by the health care pro.

This drug may be used for also the treatment of panic and axiety problems.

Exactly how to make use of Tofranil

Read the Medication Guide available from your pharmacist. Consult your pharmacist or doctor if you have any questions.

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Take this medication by mouth with or without food, frequently 1-4 times daily or as directed by the physician. If you have daytime drowsiness, your doctor may direct you to take the entire dose once daily at bedtime. Dosage is based on your medical condition and response to therapy. In children, dosage may also be based on body weight. To reduce your risk of side effects, your doctor may start you at a low dose and gradually increase your dose.

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When used in children for bed-wetting, imipramine should be taken one hour before bedtime. The drug may be given earlier in separate doses (e.g., one dose in the afternoon and one dose at bedtime) if your child usually wets the bed early in the night.

Follow your doctor's instructions very carefully. Do not take more or less medication or take it more frequently than prescribed. Your condition will perhaps not improve any faster along with your risk of side impacts will increase. Make use of this medicine frequently so that you can get the most benefit from it. To help you remember, use it at the same time(s) each time.

This medication does not away work right. It may take up to 3 weeks if you are taking this medication for depression before you experience the full benefits.

It is essential to carry on using this medication regardless if you feel good. Don't instantly stop using this medication without consulting your doctor. Some conditions may be worse once the medication is abruptly stopped. Your dose may gradually need to be decreased.

When used for a long period in children for bed-wetting, this medication may not work as well and may even require different dosing. Talk with the doctor if this medicine prevents working well.

Inform your doctor if your condition persists or worsens.

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Negative Effects

Dry mouth, blurred vision, headache, drowsiness, dizziness, constipation, nausea, vomiting, loss of appetite, diarrhea, stomach cramps, weight gain/loss, and increased sweating may occur. If any of these effects persist or worsen, notify your doctor or pharmacist quickly.

Keep in mind that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have side that is serious.

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Tell your doctor straight away if some of these unlikely but serious side effects occur: mental/mood changes (e.g., confusion, despair, memory problems), enlarged/painful breasts, unusual breast milk manufacturing, irregular/painful menstrual periods, muscle stiffness, restlessness, tinnitus, sexual issues (e.g., decreased sexual ability, alterations in desire), shakiness (tremors), numbness/tingling of the hands/feet, pain/redness/swelling of hands or feet, trouble urinating.

Inform your physician right away if any of these uncommon but really side that is serious occur: effortless bruising/bleeding, signs of infection (e.g., fever, persistent sore throat), severe stomach/abdominal pain, dark urine, yellowing of eyes/skin.

This medication may increase serotonin and rarely cause a very serious condition called serotonin syndrome/toxicity. The risk increases if you are also taking other drugs that increase serotonin, so tell your doctor or pharmacist of all the drugs you take (see Drug Interactions section). Get medical help right away if you develop some of the following symptoms: fast heartbeat, hallucinations, loss in coordination, severe dizziness, serious nausea/vomiting/diarrhea, twitching muscles, unexplained fever, uncommon agitation/restlessness.

Get medical help right away if you have any really serious side results, including: upper body pain, slow/fast/irregular heartbeat, fainting, seizures, slurred speech, weakness on one part associated with human body, attention pain/swelling/redness, eyesight changes (such as for instance seeing rainbows around lights through the night).

A really severe reaction that is allergic this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), serious dizziness, trouble respiration.

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This isn't a complete list of possible side effects. If you notice other effects not listed above, contact your pharmacist or doctor.

In america -

Call your physician for medical advice about side effects. You may report side effects to Food And Drug Administration at 1-800-FDA-1088 or at

In Canada - Call your doctor for medical advice about side results. You could report effects that are side Health Canada at 1-866-234-2345.


Before taking this medication, tell your doctor or pharmacist in the event that you are allergic to it; or to other tricyclic antidepressants (such as desipramine, amitriptyline); or if you have any other allergies. This product may contain inactive ingredients, that may cause allergic reactions or other problems. Speak with your pharmacist to get more details.

This medication must not be used if you have got a particular condition that is medical. Before using this medicine, consult your doctor or pharmacist if you have had: a heart attack that is recent.

Before making use of this medicine, tell your doctor or pharmacist your medical background, particularly of: difficulty in breathing (e.g., asthma, chronic bronchitis), personal or genealogy and family history of glaucoma (angle-closure type), diabetes, consuming disorders (e.g., bulimia), heart issues (e.g., arrhythmias, coronary artery disease), liver dilemmas, kidney problems, individual or genealogy and family history of other mental/mood conditions (e.g., manic depression, schizophrenia), seizures, overactive thyroid (hyperthyroidism), trouble urinating (e.g., due to enlarged prostate), any condition that may raise your risk of seizures (age.g., alcohol/sedative dependency, utilization of electroconvulsive therapy, brain injury/disease such as for example stroke), specific kinds of tumors (e.g., pheochromocytoma, neuroblastoma).

Imipramine may cause a condition that affects one's heart rhythm (QT prolongation). QT prolongation can hardly ever cause serious (rarely fatal) fast/irregular heartbeat as well as other symptoms (such as serious dizziness, fainting) that require medical attention appropriate away.

The risk of QT prolongation may be increased for those who have particular conditions that are medical are taking other drugs that will cause QT prolongation. Before using imipramine, inform your doctor or pharmacist of most the drugs you are taking and if you have any of the following conditions: certain heart problems (heart failure, slow heartbeat, QT prolongation into the EKG), family history of specific heart problems (QT prolongation in the EKG, unexpected cardiac death).

Low levels of potassium or magnesium in the bloodstream may also increase your risk of QT prolongation. This risk may increase if you have conditions such as severe sweating, diarrhea, or vomiting if you use certain drugs (such as diuretics/"water pills") or. Talk to your doctor about using imipramine safely.

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Before having surgery, tell your dentist or doctor that you will be taking this medication.

This drug will make you dizzy or drowsy or cause blurred vision. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely. Limit alcoholic beverages.

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To decrease dizziness and lightheadedness, get up slowly when rising from a seated or lying position.

This drug may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths, and sunlamps. Use a sunscreen and wear clothing that is protective outdoors.

If you have diabetes, this drug may make it harder to control your blood sugar levels. Check your blood sugar regularly as directed by your doctor. Tell your doctor right away if you have symptoms such as increased thirst/urination, shakiness, unusual sweating, or hunger. Your anti-diabetic medication or diet may prefer to be adjusted.

Older grownups may become more responsive to the unwanted effects of this medication, especially dizziness (more likely when standing up), drowsiness, constipation, trouble urinating, mental/mood changes (such as confusion, agitation) and heart results such as QT prolongation (see above). Dizziness, drowsiness, and confusion can boost the danger of falling.

Caution is preferred when working with this medication in children. (See also the Warning section.)

This medication should really be used only when plainly needed during pregnancy. Infants created to moms who took similar medicines during pregnancy may have symptoms such as trouble urinating, prolonged sleepiness, shaking, and seizures. Talk about the risks and benefits with your medical practitioner.

Since untreated mental/mood problems (such as depression, anxiety, panic disorders) can be a condition that is serious do not stop taking this medication unless directed by your doctor. If you are planning pregnancy, become pregnant, or think you may be pregnant, immediately discuss with your doctor the benefits and risks of using this medication during pregnancy.

This medication passes into breast milk and may have undesirable effects on a nursing infant. Consult your physician before breast-feeding.

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