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Wellbutrin (bupropion) can be an antidepressant medication. It works within the brain to deal with depression.
Wellbutrin can be used to help remedy major depressive disorder and seasonal affective disorder. At least one model of bupropion (Zyban) can be used to help stop smoking by reducing cravings and also other withdrawal effects.
Wellbutrin may also be used for other purposes unlisted on this medication guide.


Take Wellbutrin the same manner prescribed by your doctor. Do not take in larger or smaller amounts or for over recommended. Follow the directions in your prescription label.

Your doctor may occasionally change your dose to make sure you acquire the best results.

Wellbutrin might be taken with or without food.

Do not crush, chew, or break an extended-release tablet. Swallow it whole. Breaking the pill might cause too much of the drug to be sold at one time, which may increase side effects including seizures.

Do not stop taking Wellbutrin without first conversing with your physician. You may have unpleasant side effects should you stop taking this medication suddenly.

If you apply the Wellbutrin extended-release tablet, the tablet shell may pass in your stools (bowel movements). This is normal and will not mean that you are not receiving enough of the medicine.

Wellbutrin might cause you to use a false positive drug screening test. If you supply a urine sample for drug screening, tell the laboratory staff that you're taking bupropion.


Store Wellbutrin at room temperature from moisture as well as heat.

Side Effects

All medicines could cause negative effects, but many people have no, or minor, negative effects.

Check with your medical professional if some of these most popular unwanted effects persist or become bothersome:

Constipation; dizziness; drowsiness; dry mouth; flushing; headache; increased sweating; increased urination; loss of appetite; nausea; nervousness; restlessness; ringing inside ears; stomach pain; taste changes; sleep disorders; vomiting; weakness; weight changes.

Seek medical help right away if any of these severe unwanted effects occur:

Severe allergies (rash; hives; itching; lack of breath; tightness in the chest; swelling of the mouth, face, lips, or tongue, unusual hoarseness); chest pain; confusion; dark urine; delusions; fainting; fast or irregular heartbeat; fever, chills, or sore throat; hallucinations; the loss of hearing or ringing inside the ears; menstrual changes; muscle pain; new or worsening mental or mood changes (eg, concentration problems, depression, panic disorder, aggressiveness, agitation, anxiety, impulsiveness, irritability, hostility, exaggerated a sense well-being, inability to sit still); red, swollen, blistered, or peeling skin; seizures; severe headache or dizziness; severe or persistent joint or muscle pain; severe or persistent nausea, vomiting, or stomach pain; severe or persistent nervousness, restlessness, or sleep problems; lack of breath; suicidal thoughts or attempts; tremor; unusual swelling; vision changes; yellowing of the skin or eyes.

This is not a complete report on all unwanted side effects that may occur. If you might have questions regarding unwanted effects, contact your physician.


Do not take Wellbutrin if you 

Tell your medical professional in the event you have ever had depression, suicidal thoughts or actions, or any other mental medical problems.

Tell your physician about your other health conditions including in the event you:

Important safety information:

Pregnancy and breast-feeding: If you become pregnant, contact your physician. You will need to discuss the advantages and perils of using Wellbutrin while you're pregnant. Wellbutrin is found in breast milk. Do not breast-feed while taking Wellbutrin.

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