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Baclofen can be used for treating spasm of skeletal muscles that cause muscle clonus, rigidity, and pain as a result of multiple sclerosis. Baclofen relaxes skeletal muscles, the muscles that move the skeleton (also called striated muscle). Chemically, Baclofen is related to gamma-aminobutyric acid (GABA), a naturally-occurring neurotransmitter inside the brain. Neurotransmitters are chemicals that nerves use to talk with each other. GABA released by some nerves causes the activity of other nerves to reduce. It is believed that Baclofen, acting like GABA, blocks the experience of nerves from the area of the brain that controls the contraction and relaxation of skeletal muscle. Baclofen was licensed by the FDA in November, 1977.

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The usual starting dose of Baclofen for adults is 5 mg three times daily. Based on the response, the dose can be increased gradually every 72 hours to your maximum of 80 mg/day in several doses.

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Baclofen must be stored between 15°C (59°F) and 30°C (86°F). Keep Baclofen out of the reach of youngsters.

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Baclofen might cause drowsiness, weakness, dizziness, headache, seizures, nausea, vomiting, low blood pressure levels, constipation, confusion, respiratory depression, inability to sleep, and increased urinary frequency or urinary retention.

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Abrupt discontinuation of oral Baclofen could potentially cause seizures and hallucinations. Abrupt discontinuation of intrathecal Baclofen may result in high fever, rebound spasticity, muscle rigidity, and rhabdomyolysis (muscle breakdown).

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Use of Baclofen along with other drugs this depress the function of nerves can lead to additional decline in brain function.

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In addition to the probability of depressing brain function, the use of Baclofen and tricyclic antidepressants (e.g., Elavil, Sinequan) together could cause muscle weakness.

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Use of Baclofen and monoamine oxidase inhibitors (e.g. Nardil, Parnate) may result in greater depression of brain function along with low blood pressure level.

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As Baclofen can increase blood sugar, doses of antidiabetic drugs might need to be adjusted when Baclofen is taken.

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The using Baclofen by women that are pregnant hasn't been evaluated.

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Baclofen may be detected inside breast milk of mothers taking oral Baclofen. No information is entirely on the presence of Baclofen inside the breast milk of mothers receiving Baclofen intrathecally.

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