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Baclofen is utilized for treating spasm of skeletal muscles that induce muscle clonus, rigidity, and pain because of multiple sclerosis. Baclofen relaxes skeletal muscles, the muscles that move the skeleton (also called striated muscle). Chemically, Baclofen is related to gamma-aminobutyric acid (GABA), a naturally-occurring neurotransmitter inside brain. Neurotransmitters are chemicals that nerves use to speak together. GABA released by some nerves causes the adventure of other nerves to reduce. It is believed that Baclofen, acting like GABA, blocks the adventure of nerves inside the main brain that controls the contraction and relaxation of skeletal muscle. Baclofen was approved by the FDA in November, 1977.


The usual starting dose of Baclofen for adults is 5 mg thrice daily. Based on the response, the dose could be increased gradually every 3 days to a maximum of 80 mg/day in many doses.


Baclofen ought to be stored between 15°C (59°F) and 30°C (86°F). Keep Baclofen out of the reach of children.

Side Effects

Baclofen may cause drowsiness, weakness, dizziness, headache, seizures, nausea, vomiting, low blood pressure level, constipation, confusion, respiratory depression, inability to sleep, and increased urinary frequency or urinary retention.

Abrupt discontinuation of oral Baclofen might cause seizures and hallucinations. Abrupt discontinuation of intrathecal Baclofen may result in high fever, rebound spasticity, muscle rigidity, and rhabdomyolysis (muscle breakdown).


Use of Baclofen along with other drugs this depress the function of nerves may result in additional decrease in brain function.

In addition towards the probability of depressing brain function, the use of Baclofen and tricyclic antidepressants (e.g., Elavil, Sinequan) together might cause muscle weakness.

Use of Baclofen and monoamine oxidase inhibitors (e.g. Nardil, Parnate) may lead to greater depression of brain function and also low blood pressure level.

As Baclofen can increase blood sugar levels, doses of antidiabetic drugs should be adjusted when Baclofen is taken.

The use of Baclofen by expectant women has not been evaluated.

Baclofen might be detected in the breast milk of mothers taking oral Baclofen. No details are positioned on the existence of Baclofen inside the breast milk of mothers receiving Baclofen intrathecally.

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