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Uses

INDICATIONS

Indinavir is definitely an antiviral medication in a group of HIV medicines called protease (PRO-tee-ayz) inhibitors. Indinavir prevents human immunodeficiency virus (HIV) cells from multiplying in your body. It is utilized to treat HIV, which in turn causes acquired immunodeficiency syndrome (AIDS). Indinavir just isn't a cure for HIV or AIDS.

INSTRUCTIONS

Take indinavir the same manner it absolutely was prescribed in your case. Do not go ahead and take medication in larger amounts, or take it for over recommended through your doctor. Follow the directions on your own prescription label.

This medication includes patient instructions for effective and safe use. Follow these directions carefully. Ask your medical professional or pharmacist if you have any questions.
Take indinavir with a full glass (8 ounces) of water or skim milk. You might also drink juice, coffee, or tea with this medication. Drink at the very least 6 servings of water daily in order to avoid kidney stones while you are taking indinavir. Indinavir needs to be taken on jail stomach, at the very least 60 minutes before or 2 hours from a meal.

If you prefer to take the medication with food, eat simply a light meal, for example dry toast with jelly, or corn flakes with skim milk and sugar. Avoid eating a high-fat meal.

It is very important to utilize indinavir regularly to obtain the most benefit. Get your prescription refilled before you run out of drugs completely.

To make sure medicines helps your complaint, your blood must be tested often. Your liver function might also have to be tested. Do not miss any scheduled visits to your medical professional.

HIV/AIDS is often treated using a combination of different drugs. To best treat your condition, utilise all of one's medications as directed by your doctor. Be sure to read the medication guide or patient instructions supplied with each of your respective medications. Do not make positive changes to doses or medication schedule without advice from your medical professional. Every person with HIV or AIDS should remain under the proper a doctor.

Take the missed dose once you remember and take your next dose on the regularly scheduled time. If you are over couple of hours late in taking your indinavir, skip the missed dose and go ahead and take next regularly scheduled dose. Do not take extra medicine to generate up the missed dose.

DOSAGE

Usual Adult Dose for HIV Infection
800 mg orally every 8 hours or indinavir 800 mg plus ritonavir 100 mg to 200 mg orally every 12 hours.


Usual Adult Dose for Nonoccupational Exposure
800 mg orally every 8 hours or indinavir 800 mg plus ritonavir 100 mg to 200 mg orally every 12 hours.
Duration: Prophylaxis needs to be initiated at the earliest opportunity, within 72 hours of exposure, and continued for 28 days.
Indinavir plus ritonavir plus 2 NRTIs is probably the alternative regimens suitable for nonoccupational postexposure HIV prophylaxis.


Usual Adult Dose for Occupational Exposure
800 mg orally every 8 hours 800 mg orally every 8 hours plus lamivudine-zidovudine,
or indinavir 800 mg plus ritonavir 100 mg to 200 mg orally every 12 hours plus lamivudine-zidovudine.
Duration: Therapy should start promptly, preferably within 1 to a couple of hours postexposure. The exact use of therapy could differ based on the institution's protocol.

Liver Dose Adjustments
Mild to moderate hepatic insufficiency: 600 mg orally every 8 hours.


Dose Adjustments
Consider lowering the dose to 600 mg every 8 hours if delavirdine, itraconazole, or ketoconazole are administered concomitantly. Increase the dose to 1000 mg every 8 hours if rifabutin is offered concurrently, and decrease the rifabutin dose by half.
Precautions

Strict adherence towards the prescribed dose is crucial. Patients shouldn't customize the dose or discontinue therapy without consulting their physician.

Adequate hydration (1.5 liters/day) is vital during therapy to relieve the potential risk of nephrolithiasis. A brief interruption (usually 1 to 3 days) or total discontinuation could possibly be necessary if nephrolithiasis occurs.

Discontinue indinavir if hemolytic anemia occurs. Consider discontinuation if severe leukocyturia develops.

STORAGE

Store indinavir at room temperature far from moisture and heat. Keep the capsules in their original container, combined with the packet of moisture-absorbing preservative that is sold with indinavir capsules.

Side Effects

Get emergency medical help when you have any of these warning signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop taking indinavir and call a medical expert simultaneously when you have any of these serious unwanted effects:

Less serious unwanted effects may include:

This just isn't a complete set of unwanted side effects among others may occur. Tell your physician about any unusual or bothersome side-effect.

Precautions

Do not take this medication should you be allergic to indinavir.
Do not take indinavir with amiodarone (Cordarone, Pacerone), cisapride (Propulsid), pimozide (Orap), alprazolam (Xanax), oral midazolam (Versed), triazolam (Halcion), or ergot medicines such as ergotamine (Ergomar, Cafergot), dihydroergotamine (D.H.E. 45, Migranal Nasal Spray), ergonovine (Ergotrate), or methylergonovine (Methergine). These drugs can cause life-threatening side effects the use of them if you are taking indinavir.

Before taking indinavir, tell your medical professional if you're allergic to your drugs, or if you have:

If you've got any of these conditions, you need a dose adjustment or special tests to soundly take indinavir.
FDA pregnancy category C. This medication might be damaging to an baby. Tell your doctor in case you are pregnant or plan to conceive during treatment. HIV can be passed for the baby in the event the mother just isn't properly treated in pregnancy. Take all of the HIV medicines as forwarded to control your infection while you're pregnant.

Your name may have to be listed on an antiviral pregnancy registry once you begin using medicines.
You must not breast-feed while you're using indinavir. Women with HIV or AIDS should not breast-feed whatsoever. Even if your infant comes into the world without HIV, might even pass the virus to the baby with your breast milk.


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