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Precautions

Do NOT use Methotrexate if:

• you happen to be allergic to the ingredient in Methotrexate
• you're treating psoriasis or arthritis rheumatoid and you're simply pregnant or breast-feeding
• you might be treating psoriasis or rheumatism and abuse alcohol or have liver problems, an immunodeficiency syndrome (eg, AIDS), bone marrow problems, or blood problems (eg, anemia, low white blood cell count, low platelet count)
• you've got moderate or severe kidney problems
• you take acitretin.

Contact your doctor or doctor immediately if these apply to you.

Some medical ailments may interact with Methotrexate. Tell your doctor or pharmacist in case you have any health concerns, in particular when any from the following connect with you:

• if you happen to be pregnant, likely to conceive, or are breastfeeding
• if you consider any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, and other substances
• in case you have a reputation lung problems, body's defence mechanism problems, nerves problems (eg, seizures), liver problems (eg, hepatitis), or blood problems (eg, anemia, low white blood cells, low blood platelets)
• in case you have an active infection, severe vomiting or diarrhea, or dehydration
• for those who have mouth sores, excess fluid inside your stomach or around your lungs, stomach or intestinal ulcers, bowel inflammation (eg, ulcerative colitis), or a blockage of your stomach or bowel
• for those who have a vitamin b folic acid deficiency, are in inadequate health, or use a good reputation for alcohol abuse
• if you're receiving chemotherapy or radiation.

Some medicines may communicate with Methotrexate. Tell your medical provider in the event you are taking some other medicines, especially any of the following:

• Acitretin, azathioprine, etretinate, leflunomide, retinoids, or sulfasalazine because the chance of liver problems may be increased
• Chloramphenicol, corticosteroids (eg, prednisone), cyclosporine, dantrolene, hydantoins (eg, phenytoin), nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, celecoxib), penicillin antibiotics, phenylbutazone, pristinamycin, probenecid, quinolone antibiotics (eg, ciprofloxacin), salicylates (eg, aspirin), sulfonamides (eg, sulfamethoxazole), tetracycline, or trimethoprim given that they could raise the likelihood of Methotrexate's side effects
• Folic acid or leucovorin because they may decrease Methotrexate's effectiveness
• Digoxin because its effectiveness may be decreased by Methotrexate
• Anticoagulants (eg, warfarin), cyclosporine, or theophylline for the reason that likelihood of their unwanted effects might be increased by Methotrexate.

This is probably not a whole report on all interactions that could occur. Ask your doctor if Methotrexate may interact along with other medicines that you take. Check using your doctor before you start, stop, or customize the dose from a medicine.

Important safety information:

• Methotrexate could potentially cause drowsiness, dizziness, or blurred vision. These effects could be worse in case you get it with alcohol or certain medicines. Use Methotrexate with caution. Do not drive or perform other possibly unsafe tasks before you know how you answer it.
• Check with your doctor when you are drinking alcoholic beverages while you're taking Methotrexate.
• Nausea, vomiting, and lack of appetite are common with Methotrexate. Ask a medical expert or pharmacist for approaches to decrease these effects whenever they occur.
• If vomiting or diarrhea occurs, you will need to take care not to become dehydrated. Contact your doctor for instructions.
• Methotrexate could potentially cause you to become sunburned easier. Avoid the sun, sunlamps, or tanning booths unless you understand how you reply to Methotrexate. Use a sunscreen or wear protective clothing in case you has to be outside for more than a short period of time.
• Methotrexate may slow up the variety of clot-forming cells (platelets) inside your blood. Avoid activities that could cause bruising or injury. Tell your doctor for those who have unusual bruising or bleeding. Tell your doctor for those who have dark, tarry, or bloody stools.
• Methotrexate may lower the ability of your body to battle infection. Avoid contact with folks who suffer from colds or infections. Tell a medical expert in case you notice indications of infection like fever, sore throat, rash, or chills.
• Do not be given a live vaccine (eg, measles, mumps) while you are taking Methotrexate. Talk with your doctor prior to deciding to get any vaccine.
• Men who take Methotrexate should use a condom when having sexual intercourse using a woman who may become pregnant. Do this provided you take Methotrexate and then for a couple of months after you stop taking it.
• Do NOT take a lot more than the recommended dose or use for over prescribed without checking with your physician.
• Lab tests, including albumin levels, complete blood counts, and liver, lung, and kidney function, could possibly be performed as you use Methotrexate. These tests could be used to monitor your condition or look for unwanted side effects. Be sure to keep all doctor and lab appointments.
• Use Methotrexate with caution in the elderly; they might be more responsive to its effects.
• Methotrexate needs to be in combination with extreme care in children younger than a couple of years old; safety and effectiveness in these children are not confirmed.
• Pregnancy and breast-feeding: Methotrexate might cause birth defects and fetal and newborn death in the event you take it if you are pregnant. Do not get pregnant when you are deploying it. Use an effective type of birth control method while you adopt Methotrexate and for at the very least 1 ovulatory cycle as soon as you stop taking it. If you think you might be pregnant, contact your physician straight away. Methotrexate can be found in breast milk. Do not breast-feed while taking Methotrexate.