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Precautions

Do NOT use Methotrexate if:

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• you might be treating psoriasis or rheumatoid arthritis symptoms and you are pregnant or breast-feeding

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• you might be treating psoriasis or rheumatoid arthritis symptoms and abuse alcohol or have liver problems, an immunodeficiency syndrome (eg, AIDS), bone marrow problems, or blood problems (eg, anemia, low white blood cell count, low platelet count)
• you have moderate or severe kidney problems

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• you take acitretin.

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Contact your physician or health care provider immediately if some of these connect with you.

Some medical ailments may connect to Methotrexate. Tell your doctor or pharmacist if you have any health concerns, especially if any with the following connect with you:

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• if you might be pregnant, planning to become pregnant, or are breastfeeding

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• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• when you have allergies to medicines, foods, or any other substances
• if you have a history of lung problems, body's defence mechanism problems, nervous system problems (eg, seizures), liver problems (eg, hepatitis), or blood problems (eg, anemia, low white blood cells, low blood platelets)

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• if you have an active infection, severe vomiting or diarrhea, or dehydration

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• in case you have mouth sores, excess fluid in your stomach or around your lungs, stomach or intestinal ulcers, bowel inflammation (eg, ulcerative colitis), or perhaps a blockage of the stomach or bowel

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• for those who have a folate deficiency, will be in very poor health, or have a good reputation for alcohol abuse

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• if you happen to be receiving chemotherapy or radiation.

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Some medicines may talk with Methotrexate. Tell your medical provider in case you are taking any other medicines, especially any in the following:

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• Acitretin, azathioprine, etretinate, leflunomide, retinoids, or sulfasalazine as the probability of liver problems may be increased

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• Chloramphenicol, corticosteroids (eg, prednisone), cyclosporine, dantrolene, hydantoins (eg, phenytoin), nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, celecoxib), penicillin antibiotics, phenylbutazone, pristinamycin, probenecid, quinolone antibiotics (eg, ciprofloxacin), salicylates (eg, aspirin), sulfonamides (eg, sulfamethoxazole), tetracycline, or trimethoprim simply because they could raise the risk of Methotrexate's negative effects

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• Folic acid or leucovorin because they may decrease Methotrexate's effectiveness
• Digoxin because its effectiveness could possibly be decreased by Methotrexate

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• Anticoagulants (eg, warfarin), cyclosporine, or theophylline as the likelihood of their unwanted effects might be increased by Methotrexate.

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This might not be an entire list of all interactions which could occur. Ask your doctor if Methotrexate may interact along with other medicines that you take. Check using your physician before you begin, stop, or alter the dose associated with a medicine.

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Important safety information:

• Methotrexate might cause drowsiness, dizziness, or blurred vision. These effects might be worse should you go with alcohol or certain medicines. Use Methotrexate with caution. Do not drive or perform other possibly unsafe tasks unless you know how you reply to it.
• Check with your physician before you consume alcohol while you are taking Methotrexate.

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• Nausea, vomiting, and loss of appetite are normal with Methotrexate. Ask your physician or pharmacist for solutions to decrease these effects whenever they occur.

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• If vomiting or diarrhea occurs, you will need to take care not to become dehydrated. Contact your physician for instructions.

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• Methotrexate may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths unless you discover how you react to Methotrexate. Use a sunscreen or wear protective clothing in the event you has to be outside for over a small amount of time.

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• Methotrexate may decrease the number of clot-forming cells (platelets) in your blood. Avoid activities that could potentially cause bruising or injury. Tell your physician when you have unusual bruising or bleeding. Tell a medical expert in case you have dark, tarry, or bloody stools.
• Methotrexate may lower the ability of your respective body to fight infection. Avoid exposure to those who have colds or infections. Tell your physician if you notice signs and symptoms of infection like fever, sore throat, rash, or chills.

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• Do not get a live vaccine (eg, measles, mumps) if you are taking Methotrexate. Talk with your doctor before you have any vaccine.
• Men who take Methotrexate must always make use of a condom when having sexual intercourse having a woman who may become pregnant. Do this provided you're taking Methotrexate and for 3 months when you stop taking it.
• Do NOT take greater than the recommended dose or use more than prescribed without checking with a medical expert.

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• Lab tests, including albumin levels, complete blood counts, and liver, lung, and kidney function, could possibly be performed while you use Methotrexate. These tests may be used to monitor your problem or search for unwanted effects. Be sure to keep all doctor and lab appointments.
• Use Methotrexate with caution inside elderly; they could be more sensitive to its effects.

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• Methotrexate needs to be used with warning in kids younger than two years old; safety and effectiveness during these children have not been confirmed.

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• Pregnancy and breast-feeding: Methotrexate could cause birth defects and fetal and newborn death should you go on it while you are pregnant. Do not become pregnant while you are deploying it. Use an effective form of contraceptive while you are taking Methotrexate as well as for at least 1 ovulatory cycle as soon as you stop taking it. If you think you could possibly be pregnant, contact your medical professional right away. Methotrexate is located in breast milk. Do not breast-feed while taking Methotrexate.

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