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Promethazine is a small grouping of drugs called phenothiazines (FEEN-oh-THYE-a-zeens). It works by changing the actions of chemicals within your brain. Promethazine also acts as a possible antihistamine. It blocks the consequences with the naturally sourced chemical histamine with your body.

Promethazine can be used to treat hypersensitivity like itching, runny nose, sneezing, itchy or watery eyes, hives, and itchy skin rashes.

Promethazine also prevents motion sickness, and treats nausea and vomiting or pain after surgery. It is also used as a sedative or sleep aid.

Promethazine is not to be used for signs of asthma, pneumonia, or another lower respiratory tract infections.

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Take promethazine the same manner prescribed from your doctor. Do not take it in larger amounts or more than recommended. Follow the directions on your prescription label.

Your doctor may occasionally make positive changes to dose to make sure you receive the best comes from this medication.

Promethazine might be taken with or without food or milk.

Measure liquid medicine with a marked measuring spoon or medicine cup, not with a regular table spoon. If you tend not to have a very dose-measuring device, ask the pharmacist for just one.

Call your doctor should your symptoms do not improve, or if they deteriorate while taking promethazine.

This medication could cause one to have unusual results with certain tests. Tell any doctor who treats you that you're using promethazine.

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Seek emergency medical help if you feel you've got used an excessive amount this medicine. Overdose symptoms can sometimes include severe drowsiness, dizziness, dry mouth, large pupils, flushing, nausea, vomiting, shallow breathing, and fainting.


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Take becoming prescribed through your doctor.

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Store promethazine at room temperature far from moisture, heat, and light.

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Side Effects

Get emergency medical help if you might have these signs and symptoms of a hypersensitivity: hives; lack of breath; swelling of your face, lips, tongue, or throat. Stop using promethazine and call your physician at once if you might have these serious unwanted side effects:

twitching, or uncontrollable movements of the eyes, lips, tongue, face, arms, or legs;

tremor (uncontrolled shaking), drooling, trouble swallowing, difficulty with balance or walking;

feeling restless, jittery, or agitated;

high fever, stiff muscles, confusion, sweating, fast or uneven heartbeats, rapid breathing;

feeling as you might pass out;

seizure (convulsions);

pale skin, easy bruising or bleeding, fever, sore throat, flu symptoms;

decreased night vision, tunnel vision, watery eyes, increased sensitivity to light;

hallucinations, agitation;

nausea and stomach pain, skin rash, and jaundice (yellowing from the skin or eyes);

urinating below usual or not whatsoever;

joint pain or swelling with fever, swollen glands, muscle aches, chest pain, vomiting, unusual thoughts or behavior, and patchy skin tone; or

slow pulse rate, weak pulse, fainting, slow breathing (breathing may stop).

Less serious promethazine negative effects can sometimes include:

dizziness, drowsiness, anxiety;

blurred vision, dry mouth, stuffy nose;

ringing with your ears;

weight gain, swelling in your hands or feet;

impotence, trouble through an orgasm; or


This isn't a complete report on unwanted side effects while others may occur. Tell your doctor about any unusual or bothersome side effect.


Stop using promethazine and call your physician at once if you might have twitching or uncontrollable movements of one's eyes, lips, tongue, face, arms, or legs. These could be early signs and symptoms of dangerous negative effects. Promethazine can cause unwanted side effects that will impair your notions or reactions. Be careful in the event you drive or do anything that will require that you be awake and alert. Avoid having a drink, which could increase some from the negative effects of promethazine. There are many other medicines that can communicate with promethazine. Tell your physician about all of the prescription and over-the-counter medications you utilize. This includes vitamins, minerals, herbal products, and prescriptions given by other doctors. Do not employ a new medication without telling your medical professional. Keep a list along of every one of the medicines you employ and show this list to the doctor or other healthcare provider who treats you.

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Important safety information:

Promethazine shouldn't be presented to a child younger than a couple of years old. Promethazine can cause severe breathing problems or death in a young child younger than 2. Carefully follow your doctor's instructions when giving this medicine to a young child of any age. Do not use this medication if you've got severe asthma, emphysema, or any other breathing problem, or if you are allergic to promethazine and other phenothiazines including chlorpromazine (Thorazine), fluphenazine (Permitil), perphenazine (Trilafon), prochlorperazine (Compazine, Compro), thioridazine (Mellaril), or trifluoperazine (Stelazine).

If you have certain conditions, you might need a dose adjustment or special tests to securely use prescription drugs. Before you take promethazine, tell your physician if you've got:

a good seizures;

heart disease or hypertension;

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liver or kidney disease;

severe asthma, emphysema, chronic obstructive pulmonary disease (COPD) or another breathing problem;

sleep apnea (breathing stops during sleep);


a stomach ulcer or digestive obstruction;

bone marrow depression;

adrenal gland tumor (pheochromocytoma);

enlarged prostate or difficulty with urination;

low degrees of calcium in your blood (hypocalcemia); or

if you've got ever stood a serious side-effect while using promethazine or other phenothiazine.

FDA pregnancy category C. It just isn't known whether promethazine is harmful to a child. Tell your medical professional in case you are pregnant or plan to conceive during treatment. It is just not known whether promethazine passes into breast milk or if it could harm a nursing baby. Do not use medicines without telling your medical professional in case you are breast-feeding your baby. Older adults may be prone to have unwanted side effects from promethazine.

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