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Precautions

Do NOT use Zestoretic if:

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• you are allergic to the ingredient in Zestoretic or other sulfonamide medicine (eg, sulfamethoxazole, glyburide, probenecid)
• you have a very history of angioedema (swelling with the face, lips, throat, or tongue)
• you have a history of kidney artery narrowing

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• you cannot urinate

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• you are taking dofetilide or ketanserin
• you might be pregnant.

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Contact your physician or physician right away if any of these affect you.

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Some medical ailments may communicate with Zestoretic. Tell a medical expert or pharmacist in case you have any health conditions, particularly when any of the following connect with you:

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• if you are pregnant, about to become pregnant, or are breast-feeding

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• in the event you take any prescription or nonprescription medicine, herbal preparation, or dietary supplement

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• when you have allergies to medicines, foods, or other substances

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• if you are able to become pregnant

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• in case you have impaired liver function, blood vessel problems (eg, stroke), cardiovascular disease (eg, congestive heart failure), or high cholesterol

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• in case you use a history of kidney artery narrowing or decreased kidney function, you happen to be on dialysis, or you have had a kidney transplant

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• in case you have gout, diabetes, or electrolyte imbalances (eg, high or low potassium levels, low blood sodium levels), or you might be on the sodium-restricted diet

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Some medicines may communicate with Zestoretic. Tell your health care provider in case you consider any other medicines, especially any of the following:

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• Aldosterone blockers (eg, eplerenone), corticosteroids (eg, prednisone), digoxin, dofetilide, ketanserin, lithium, loop diuretics (eg, furosemide), potassium preparations, potassium-sparing diuretics (eg, triameterene), or trimethoprim because the probability of electrolyte problems and irregular heartbeat might be increased
• Barbiturates (eg, phenobarbital), dextran sulfate, diazoxide, or narcotic pain medicine (eg, codeine) because the probability of low hypertension could be increased

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• Gold-containing medicines (eg, sodium aurothiomalate) because flushing, nausea, vomiting, and low hypertension may occur

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• Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, indomethacin, celecoxib) or salicylates (eg, aspirin) since they may decrease Zestoretic's effectiveness
• Insulin, sulfonylureas (eg, glyburide), or other medicines for diabetes (eg, metformin) as their effectiveness might be decreased by Zestoretic.

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This might not be a complete set of all interactions that may occur. Ask your health care provider if Zestoretic may connect to other medicines that you take. Check with your medical provider before you start, stop, or alter the dose of any medicine.

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Important safety information:

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• Zestoretic could cause dizziness, lightheadedness, or fainting. These effects may be worse if you're taking it with alcohol or certain medicines. Use Zestoretic with caution. Do not drive or perform other possible unsafe tasks before you understand how you react to it.
• Zestoretic could potentially cause dizziness, lightheadedness, or fainting; alcohol, summer, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or sleep the night in the first sign from a of these effects.

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• Check along with your doctor prior to deciding to use a salt substitute or even a creation that has potassium in it.
• Drink plenty of fluids while taking Zestoretic and steer clear of engaging in activities that create sweating. Dehydration, excessive sweating, vomiting, or diarrhea may result in a fall in blood pressure level. Contact your health care provider simultaneously if some of these occur.

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• Diabetes patients - Zestoretic may raise your blood sugar levels. High blood sugar levels might make you're feeling confused, drowsy, or thirsty. It can also make you flush, breathe faster, or possess a fruit-like breath odor. If these symptoms occur, tell your physician straight away.
• A persistent, unproductive cough may occur. Tell your physician if this type of occurs. Recovery is rapid once the medicine is stopped.

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• Patients having medicine for high blood pressure often feel tired or shabby for some weeks after starting treatment. Be sure to take your medicine even if you may well not feel "normal." Tell a medical expert in the event you develop any new symptoms.
• Zestoretic may well not act as well in black patients. They may even be at greater likelihood of negative effects. Contact your doctor if your symptoms do not improve or if they become worse.
• Tell a medical expert or dentist that you adopt Zestoretic prior to deciding to get any medical or dental hygiene, emergency care, or surgery.

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• Zestoretic could potentially cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you understand how you respond to Zestoretic. Use a sunscreen or wear protective clothing in case you have to be outside for more than a short time.

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• Zestoretic may restrict certain lab tests, including parathyroid function tests. Be sure a medical expert and lab personnel know you are taking Zestoretic.

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• Lab tests, including blood electrolytes, blood pressure level, complete blood cell counts, and kidney function, could possibly be performed whilst you use Zestoretic. These tests could be used to monitor your condition or search for negative effects. Be sure to keep all doctor and lab appointments.
• Use Zestoretic with caution within the elderly; they may be more sensitive to its effects.

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• Zestoretic needs to be used with extreme caution in youngsters; safety and effectiveness in youngsters haven't been confirmed.

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• Pregnancy and breast-feeding: Zestoretic could cause birth defects or fetal death if you're taking it while you happen to be pregnant. If you think you could be pregnant, speak to your doctor right away. Zestoretic is found in breast milk. Do not breastfeed while taking Zestoretic.

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